Polymyalgia Rheumatica (PMR)

Polymyalgia Rheumatica (PMR) is an inflammatory disorder that primarily affects older adults, causing widespread muscle pain and stiffness.

The condition most commonly manifests in individuals over the age of 50 and is more prevalent among women than men. While the exact cause of PMR remains unknown, it is thought to involve a combination of genetic predisposition and environmental factors, such as infections, that may trigger an abnormal immune response.

What Are the Signs/Symptoms?

The hallmark symptoms of PMR include:

• Muscle pain and stiffness: These are most pronounced in the shoulders, neck, hips, and thighs. The stiffness is typically worse in the morning or after periods of inactivity.
• Fatigue: Many individuals report feeling unusually tired or weak.
• Reduced range of motion: Difficulty with everyday activities, such as dressing, standing, or climbing stairs, is common.
• Low-grade fever and weight loss: Some people may experience systemic symptoms like fever or unintended weight loss.

What Are Common Treatments?

The cornerstone of PMR treatment is corticosteroids, such as prednisone, which are highly effective in reducing inflammation and alleviating symptoms. Most patients experience significant improvement within days of starting therapy. However, treatment usually continues for 1-2 years, with the dose gradually tapered to the lowest effective amount to minimize side effects.

Nonsteroidal anti-inflammatory drugs (NSAIDs) and physical therapy may also be used as adjunct therapies. In some cases, immunosuppressive medications like methotrexate are prescribed if corticosteroids alone are insufficient or if there are concerns about long-term steroid use.